Helios deficiency has minimal impact on T cell development and function
- PMID: 19620299
- DOI: 10.4049/jimmunol.0901407
Helios deficiency has minimal impact on T cell development and function
Abstract
Helios is a member of the Ikaros family of zinc finger transcription factors. It is expressed mainly in T cells, where it associates with Ikaros-containing complexes and has been proposed to act as a rate-limiting factor for Ikaros function. Overexpression of wild-type or dominant-negative Helios isoforms profoundly alters alphabeta T cell differentiation and activation, and endogenous Helios is expressed at strikingly high levels in regulatory T cells. Helios has also been implicated as a tumor suppressor in human T cell acute lymphoblastic leukemias. These studies suggest a central role for Helios in T cell development and homeostasis, but whether this protein is physiologically required in T cells is unclear. We report herein that inactivation of the Helios gene by homologous recombination does not impair the differentiation and effector cell function of alphabeta and gammadelta T cells, NKT cells, and regulatory T cells. These results suggest that Helios is not essential for T cells, and that its function can be compensated for by other members of the Ikaros family.
Similar articles
-
Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.Eur J Immunol. 2007 Dec;37(12):3551-63. doi: 10.1002/eji.200737130. Eur J Immunol. 2007. PMID: 18034420
-
Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells".J Immunol. 2010 Dec 15;185(12):7129; author reply 7130. doi: 10.4049/jimmunol.1090105. J Immunol. 2010. PMID: 21127313 No abstract available.
-
The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15712-7. doi: 10.1073/pnas.0405546101. Epub 2004 Oct 20. Proc Natl Acad Sci U S A. 2004. PMID: 15496469 Free PMC article.
-
The role of the Ikaros gene in lymphocyte development and homeostasis.Annu Rev Immunol. 1997;15:155-76. doi: 10.1146/annurev.immunol.15.1.155. Annu Rev Immunol. 1997. PMID: 9143685 Review.
-
Stem cell-like plasticity of naïve and distinct memory CD8+ T cell subsets.Semin Immunol. 2009 Apr;21(2):62-8. doi: 10.1016/j.smim.2009.02.004. Epub 2009 Mar 9. Semin Immunol. 2009. PMID: 19269852 Review.
Cited by
-
Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77.J Immunol. 2019 Oct 15;203(8):2163-2170. doi: 10.4049/jimmunol.1900559. Epub 2019 Sep 16. J Immunol. 2019. PMID: 31527196 Free PMC article.
-
Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function.Immunol Rev. 2021 Mar;300(1):82-99. doi: 10.1111/imr.12936. Epub 2020 Dec 17. Immunol Rev. 2021. PMID: 33331000 Free PMC article. Review.
-
HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival.FASEB J. 2019 Apr;33(4):5220-5236. doi: 10.1096/fj.201802017R. Epub 2019 Jan 8. FASEB J. 2019. PMID: 30620626 Free PMC article.
-
Role of a non-canonical splice variant of the Helios gene in the differentiation of acute lymphoblastic leukemic T cells.Oncol Lett. 2018 May;15(5):6957-6966. doi: 10.3892/ol.2018.8214. Epub 2018 Mar 8. Oncol Lett. 2018. PMID: 29725423 Free PMC article.
-
Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.Cytokine. 2011 Mar;53(3):271-81. doi: 10.1016/j.cyto.2010.11.013. Epub 2010 Dec 16. Cytokine. 2011. PMID: 21163671 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases