Review
doi: 10.1093/abbs/gmp031.
The lysosome and neurodegenerative diseases
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- PMID: 19499146
- DOI: 10.1093/abbs/gmp031
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Review
The lysosome and neurodegenerative diseases
Acta Biochim Biophys Sin (Shanghai).
2009 Jun.
Free article
Abstract
It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.
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