Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA
- PMID: 19449440
- DOI: 10.1002/biof.14
Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA
Erratum in
- Biofactors. 2009 Sep-Oct;35(5):468
Abstract
The mitochondrial theory of aging is the idea that age-associated mitochondrial dysfunction is caused by accumulation of somatic mutations in mitochondrial DNA (mtDNA). However, mitochondria are considered to be a dynamic organelle that repeats fusion and fission. Through fusion and fission, there is an extensive and continuous exchange of mtDNA and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiratory dysfunction caused by pathogenic mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the mitochondrial theory of aging. Moreover, the presence of mitochondrial complementation enables gene therapy for mitochondrial diseases using nuclear transplantation of zygotes. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.
Similar articles
-
Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.Biochim Biophys Acta. 2006 May-Jun;1763(5-6):473-81. doi: 10.1016/j.bbamcr.2006.03.001. Epub 2006 Mar 24. Biochim Biophys Acta. 2006. PMID: 16624428 Review.
-
Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria.Nat Genet. 2001 Jul;28(3):272-5. doi: 10.1038/90116. Nat Genet. 2001. PMID: 11431699
-
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes.Nat Genet. 2000 Oct;26(2):176-81. doi: 10.1038/82826. Nat Genet. 2000. PMID: 11017072
-
Interaction theory of mammalian mitochondria.Biochem Biophys Res Commun. 2001 Nov 9;288(4):743-6. doi: 10.1006/bbrc.2001.5838. Biochem Biophys Res Commun. 2001. PMID: 11688969
-
Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.Chang Gung Med J. 2009 Mar-Apr;32(2):113-32. Chang Gung Med J. 2009. PMID: 19403001 Review.
Cited by
-
The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.Cells. 2023 Jul 20;12(14):1897. doi: 10.3390/cells12141897. Cells. 2023. PMID: 37508561 Free PMC article. Review.
-
Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling.Immunol Rev. 2011 Sep;243(1):215-34. doi: 10.1111/j.1600-065X.2011.01038.x. Immunol Rev. 2011. PMID: 21884179 Free PMC article. Review.
-
Amyloid β Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics.Mol Neurobiol. 2019 Jun;56(6):3922-3936. doi: 10.1007/s12035-018-1342-z. Epub 2018 Sep 18. Mol Neurobiol. 2019. PMID: 30225776
-
Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging.Genome Biol. 2020 Sep 17;21(1):248. doi: 10.1186/s13059-020-02138-5. Genome Biol. 2020. PMID: 32943091 Free PMC article.
-
Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.Geroscience. 2024 Jul 19. doi: 10.1007/s11357-024-01276-z. Online ahead of print. Geroscience. 2024. PMID: 39028454
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources