Cardioprotection by vanadium compounds targeting Akt-mediated signaling
- PMID: 19423951
- DOI: 10.1254/jphs.09r01cr
Cardioprotection by vanadium compounds targeting Akt-mediated signaling
Abstract
Treatment with inorganic and organic compounds of vanadium has been shown to exert a wide range of cardioprotective effects in myocardial ischemia/reperfusion-induced injury, myocardial hypertrophy, hypertension, and vascular diseases. Furthermore, administration of vanadium compounds improves cardiac performance and smooth muscle cell contractility and modulates blood pressure in various models of hypertension. Like other vanadium compounds, we documented bis(1-oxy-2-pyridinethiolato) oxovanadium (IV) [VO(OPT)] as a potent cardioprotective agent to elicit cardiac functional recovery in myocardial infarction and pressure overload-induced hypertrophy. Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia/reperfusion-induced injury and myocardial hypertrophy. Vanadium compounds also promote cardiac functional recovery by stimulation of glucose transport in diabetic heart. We here discuss the current understanding of mechanisms underlying vanadium compound-induced cardioprotection and propose a novel therapeutic strategy targeting for Akt signaling to rescue cardiomyocytes from heart failure.
Similar articles
-
Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection.Expert Opin Ther Targets. 2008 Oct;12(10):1217-27. doi: 10.1517/14728222.12.10.1217. Expert Opin Ther Targets. 2008. PMID: 18781821 Review.
-
Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.Eur J Pharmacol. 2007 Oct 1;571(2-3):180-8. doi: 10.1016/j.ejphar.2007.05.046. Epub 2007 Jun 9. Eur J Pharmacol. 2007. PMID: 17658509
-
Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats.Hypertension. 2009 Jan;53(1):57-63. doi: 10.1161/HYPERTENSIONAHA.108.118356. Epub 2008 Nov 24. Hypertension. 2009. PMID: 19029487
-
[Benefit of vanadium compound in therapy for cardiovascular diseases].Yakugaku Zasshi. 2012;132(3):279-84. doi: 10.1248/yakushi.132.279. Yakugaku Zasshi. 2012. PMID: 22382830 Review. Japanese.
-
Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein.Cardiovasc Ther. 2008 Spring;26(1):10-23. doi: 10.1111/j.1527-3466.2008.00039.x. Cardiovasc Ther. 2008. PMID: 18466417
Cited by
-
Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate.Food Sci Biotechnol. 2018 Aug 3;28(1):209-214. doi: 10.1007/s10068-018-0436-8. eCollection 2019 Feb. Food Sci Biotechnol. 2018. PMID: 30815312 Free PMC article.
-
Overview of Research on Vanadium-Quercetin Complexes with a Historical Outline.Antioxidants (Basel). 2022 Apr 17;11(4):790. doi: 10.3390/antiox11040790. Antioxidants (Basel). 2022. PMID: 35453475 Free PMC article. Review.
-
Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand.Biomedicines. 2022 May 24;10(6):1217. doi: 10.3390/biomedicines10061217. Biomedicines. 2022. PMID: 35740239 Free PMC article.
-
Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans.J Clin Cell Immunol. 2015 Feb;6(1):285. doi: 10.4172/2155-9899.1000285. J Clin Cell Immunol. 2015. PMID: 25995968 Free PMC article.
-
Association of urinary metal profiles with serum uric acid: a cross-sectional study of traffic policemen in Wuhan, China.BMJ Open. 2019 May 10;9(5):e022542. doi: 10.1136/bmjopen-2018-022542. BMJ Open. 2019. PMID: 31079077 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
