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. 2009 Sep;24(9):1565-71.
doi: 10.1359/jbmr.090414.

Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture

Samuel Gourion-Arsiquaud  1 , Dan Faibish, Elizabeth Myers, Lyudmila Spevak, Juliet Compston, Anthony Hodsman, Elizabeth Shane, Robert R Recker, Elizabeth R Boskey, Adele L Boskey
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Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture

Samuel Gourion-Arsiquaud et al. J Bone Miner Res. 2009 Sep.

Abstract

BMD does not entirely explain an individual's risk of fracture. The purpose of this study was to assess whether specific differences in spatially resolved bone composition also contribute to fracture risk. These differences were assessed using Fourier transform infrared spectroscopic imaging (FTIRI) and analyzed through multiple logistic regression. Models were constructed to determine whether FTIRI measured parameters describing mineral content, mineral crystal size and perfection, and collagen maturity were associated with fracture. Cortical and cancellous bone were independently evaluated in iliac crest biopsies from 54 women (32 with fractures, 22 without) who had significantly different spine but not hip BMDs and ranged in age from 30 to 83 yr. The parameters that were significantly associated with fracture in the model were cortical and cancellous collagen maturity (increased with increased fracture risk), cortical mineral/matrix ratio (higher with increased fracture risk), and cancellous crystallinity (increased with increased fracture risk). As expected, because of its correlation with cortical but not cancellous bone density, hip BMD was significantly associated with fracture risk in the cortical but not the cancellous model. This research suggests that additional parameters associated with fracture risk should be targeted for therapies for osteoporosis.

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Figures

FIG. 1
FIG. 1
Typical infrared images for the FTIR parameters recorded in trabecular bone from two patients, one with fractures and one without, who had comparable BMD T-scores of −1.3. Patient A had no fractures (t = −1.32) and was 50 yr old at time of biopsy. Patient B had a fracture history (T = −1.25) and was 58 yr old at time of biopsy. Numerical values below the images are the means ± SD for that parameter in the figure and indicate the range of data for the pixels shown. Note in these figures, 1 pixel = 6.25 μm.
FIG. 2
FIG. 2
Summary of measured FTIRI parameters for all cases; mean ± SD. *p < 0.05 vs. nonfracture controls; **p < 0.01 vs. nonfracture controls.
See this image and copyright information in PMC

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