Review
doi: 10.1080/10641960902822468.
Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders
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- PMID: 19387897
- DOI: 10.1080/10641960902822468
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Review
Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders
Clin Exp Hypertens.
2009 May.
Free article
Abstract
Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock. Plasma PAI-1 levels are increased in the beginning of the active phase in both diurnal humans and in nocturnal rodents, suggesting that the rhythmic PAI-1 expression is commonly indispensable for organisms. A series of our recent studies revealed that circadian clock proteins are important for hypofibrinolysis induced by metabolic disorders such as obesity and diabetes.
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