Review
doi: 10.1159/000235342.
Control of eosinophilia
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- PMID: 1937865
- DOI: 10.1159/000235342
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Review
Control of eosinophilia
Int Arch Allergy Appl Immunol.
1991.
Abstract
Experiments in vitro have suggested that IL5 is a late-acting factor in eosinophil production, and that other factors such as IL3, G-CSF and GM-CSF are required for the production of committed eosinophil progenitors. Furthermore, work in vitro indicates that in addition to IL5, both IL3 and GM-CSF are capable of stimulating eosinophil differentiation. Thus, there would appear to be both considerable redundancy in cytokine actions in eosinophilia as well as a complex network of cytokine activities to induce eosinophilia. Experiments in vivo, however, suggest a less complicated control mechanism, dominated by IL5.
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