Comment
doi: 10.1016/j.cell.2009.03.024.
A Nurr1 pathway for neuroprotection
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- PMID: 19345183
- DOI: 10.1016/j.cell.2009.03.024
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Comment
A Nurr1 pathway for neuroprotection
Cell.
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Abstract
Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.
Comment on
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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death.Cell. 2009 Apr 3;137(1):47-59. doi: 10.1016/j.cell.2009.01.038. Cell. 2009. PMID: 19345186 Free PMC article.
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