The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

doi:10.1038/nature07961

Review

. 2009 Mar 26;458(7237):445-52.

doi: 10.1038/nature07961.

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Camilla Raiborg¹, Harald Stenmark

Affiliations

PMID: 19325624
DOI: 10.1038/nature07961

Review

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

Camilla Raiborg et al. Nature. 2009.

. 2009 Mar 26;458(7237):445-52.

doi: 10.1038/nature07961.

Authors

Camilla Raiborg¹, Harald Stenmark

Affiliation

¹ Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway.

PMID: 19325624
DOI: 10.1038/nature07961

Abstract

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral budding, it mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane. The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell.

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References

1. Traffic. 2008 Sep;9(10):1698-716 - PubMed
1. J Biol Chem. 2005 May 20;280(20):19600-6 - PubMed
1. Nat Cell Biol. 2003 May;5(5):461-6 - PubMed
1. Development. 2006 Dec;133(23):4679-89 - PubMed
1. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31 - PubMed

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[1] Traffic. 2008 Sep;9(10):1698-716 - PubMed

[2] Traffic. 2008 Sep;9(10):1698-716 - PubMed

[3] J Biol Chem. 2005 May 20;280(20):19600-6 - PubMed

[4] J Biol Chem. 2005 May 20;280(20):19600-6 - PubMed

[5] Nat Cell Biol. 2003 May;5(5):461-6 - PubMed

[6] Nat Cell Biol. 2003 May;5(5):461-6 - PubMed

[7] Development. 2006 Dec;133(23):4679-89 - PubMed

[8] Development. 2006 Dec;133(23):4679-89 - PubMed

[9] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31 - PubMed

[10] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31 - PubMed

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

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