Review
doi: 10.2174/157016209787581418.
Role of Vpr in HIV-1 nuclear import: therapeutic implications
Affiliations
- PMID: 19275582
- DOI: 10.2174/157016209787581418
Item in Clipboard
Review
Role of Vpr in HIV-1 nuclear import: therapeutic implications
Curr HIV Res.
2009 Mar.
Abstract
The replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells, such as terminally differentiated macrophages, critically depends on the import of the viral pre-integration complex (PIC) into the nucleus. Vpr, one of the accessory gene products of HIV-1, plays a key regulatory role in PIC nuclear import in macrophages, although its role in the PIC entry mechanism remains to be clarified. Here, we summarize what is currently known about the nuclear-entry step of HIV-1 replication, mainly focusing on how Vpr functions as the main regulator of HIV-1 nuclear import and how it could facilitate the development of novel inhibitors of this process.
Similar articles
-
Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages.J Virol. 2007 May;81(10):5284-93. doi: 10.1128/JVI.01928-06. Epub 2007 Mar 7. J Virol. 2007. PMID: 17344301 Free PMC article.
-
Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages.J Virol. 2003 Jul;77(13):7582-9. doi: 10.1128/jvi.77.13.7582-7589.2003. J Virol. 2003. PMID: 12805458 Free PMC article.
-
Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?Curr Drug Targets. 2003 Jul;4(5):409-29. doi: 10.2174/1389450033490984. Curr Drug Targets. 2003. PMID: 12816349 Review.
-
Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex.J Mol Biol. 2000 Jun 2;299(2):359-68. doi: 10.1006/jmbi.2000.3768. J Mol Biol. 2000. PMID: 10860744
-
Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm.Curr Med Chem. 2010;17(6):495-503. doi: 10.2174/092986710790416335. Curr Med Chem. 2010. PMID: 20015032 Review.
Cited by
-
Viral replication is enhanced by an HIV-1 intersubtype recombination-derived Vpu protein.Virol J. 2010 Oct 4;7:259. doi: 10.1186/1743-422X-7-259. Virol J. 2010. PMID: 20920359 Free PMC article.
-
The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells.Cancer Cell Int. 2009 Aug 12;9:20. doi: 10.1186/1475-2867-9-20. Cancer Cell Int. 2009. PMID: 19674438 Free PMC article.
-
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr.PLoS One. 2011;6(11):e27815. doi: 10.1371/journal.pone.0027815. Epub 2011 Nov 16. PLoS One. 2011. PMID: 22110766 Free PMC article.
-
Visualizing Vpr-induced G2 arrest and apoptosis.PLoS One. 2014 Jan 22;9(1):e86840. doi: 10.1371/journal.pone.0086840. eCollection 2014. PLoS One. 2014. PMID: 24466265 Free PMC article.
-
Therapeutic Potential of Spirooxindoles as Antiviral Agents.ACS Infect Dis. 2016 Jun 10;2(6):382-92. doi: 10.1021/acsinfecdis.6b00041. Epub 2016 May 5. ACS Infect Dis. 2016. PMID: 27627626 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
