Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
- PMID: 19254698
- DOI: 10.1016/j.bbrc.2009.02.131
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
Abstract
Adiponectin, one of the insulin-sensitizing adipokines, has been shown to activate fatty acid oxidation in liver and skeletal muscle, thus maintaining insulin sensitivity. However, the precise roles of adiponectin in fatty acid synthesis are poorly understood. Here we show that adiponectin administration acutely suppresses expression of sterol regulatory element-binding protein (SREBP) 1c, the master regulator which controls and upregulates the enzymes involved in fatty acid synthesis, in the liver of +Lepr(db)/+Lepr(db) (db/db) mouse as well as in cultured hepatocytes. We also show that adiponectin suppresses SREBP1c by AdipoR1, one of the functional receptors for adiponetin, and furthermore that suppressing either AMP-activated protein kinase (AMPK) via its upstream kinase LKB1 deletion cancels the negative effect of adiponectin on SREBP1c expression. These data show that adiponectin suppresses SREBP1c through the AdipoR1/LKB1/AMPK pathway, and suggest a possible role for adiponectin in the regulation of hepatic fatty acid synthesis.
Similar articles
-
SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease.Int J Mol Med. 2008 Apr;21(4):507-11. Int J Mol Med. 2008. PMID: 18360697
-
Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.Metabolism. 2011 Jun;60(6):805-14. doi: 10.1016/j.metabol.2010.07.032. Epub 2010 Sep 16. Metabolism. 2011. PMID: 20846698
-
Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes.J Steroid Biochem Mol Biol. 2013 Nov;138:445-54. doi: 10.1016/j.jsbmb.2013.08.013. Epub 2013 Aug 30. J Steroid Biochem Mol Biol. 2013. PMID: 23994141
-
Adiponectin--a key adipokine in the metabolic syndrome.Diabetes Obes Metab. 2006 May;8(3):264-80. doi: 10.1111/j.1463-1326.2005.00510.x. Diabetes Obes Metab. 2006. PMID: 16634986 Review.
-
Adiponectin and alcoholic fatty liver disease.IUBMB Life. 2008 Dec;60(12):790-7. doi: 10.1002/iub.124. IUBMB Life. 2008. PMID: 18709650 Review.
Cited by
-
Tissue-specific role and associated downstream signaling pathways of adiponectin.Cell Biosci. 2021 Apr 26;11(1):77. doi: 10.1186/s13578-021-00587-4. Cell Biosci. 2021. PMID: 33902691 Free PMC article. Review.
-
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway?Onco Targets Ther. 2017 Mar 3;10:1403-1412. doi: 10.2147/OTT.S111681. eCollection 2017. Onco Targets Ther. 2017. PMID: 28424556 Free PMC article. Review.
-
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.Sci Rep. 2020 Dec 3;10(1):21102. doi: 10.1038/s41598-020-78166-9. Sci Rep. 2020. PMID: 33273564 Free PMC article.
-
Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer.Int J Mol Sci. 2021 Feb 22;22(4):2163. doi: 10.3390/ijms22042163. Int J Mol Sci. 2021. PMID: 33671547 Free PMC article. Review.
-
Mechanisms of Chronic Metabolic Stress in Arrhythmias.Antioxidants (Basel). 2020 Oct 19;9(10):1012. doi: 10.3390/antiox9101012. Antioxidants (Basel). 2020. PMID: 33086602 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
