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. 2009 Mar;17(3):525-31.
doi: 10.1038/oby.2008.556. Epub 2008 Dec 25.

A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study

Jun Wu  1 , James S Pankow, Russell P Tracy, Kari E North, Richard H Myers, Mary E Feitosa, Michael A Province, Ingrid B Borecki
Affiliations

A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study

Jun Wu et al. Obesity (Silver Spring). 2009 Mar.

Abstract

It has been recognized that obese individuals are intrinsically in a state of chronic inflammation, as indicated by positive correlations between serum levels of C-reactive protein (CRP) and various anthropometric measures of obesity. To explore the hypothesis that a gene(s) may underlie this relationship, we conducted bivariate linkage analyses of BMI and CRP in white and African-American (AA) families of the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study (FHS). Variance components linkage analysis as implemented in SOLAR was performed in 1,825 whites (840 men and 985 women) and 548 AAs (199 men and 351 women). CRP exhibited significant genetic correlations with BMI in women (0.54 +/- 0.10 for white and 0.53 +/- 0.14 for AA) and the combined samples (0.37 +/- 0.09 for white and 0.56 +/- 0.13 for AA), but not in men. We detected a maximum bivariate lod score of 3.86 on chromosome 12q24.2-24.3 at 139 cM and a suggestive linkage signal (lod = 2.19) on chromosome 19p13.1 (44 cM) in white women. Both bivariate peaks were substantially higher than their respective univariate lods at the same locus for each trait. No significant lod scores were detected in AAs. Our results indicate that chromosome 12q may harbor quantitative trait loci (QTLs) jointly regulating BMI and CRP in white women.

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Conflict of interest statement

DISCLOSURE

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Lod scores on chromosome 12 of univariate and bivariate linkage analysis for CRP and BMI in white women. CRP, C-reactive protein.
See this image and copyright information in PMC

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