[Evolutionary engineering in Salmonella: emergence of hybrid virulence-resistance plasmids in non-typhoid serotypes]
- PMID: 19218002
- DOI: 10.1016/j.eimc.2008.09.001
[Evolutionary engineering in Salmonella: emergence of hybrid virulence-resistance plasmids in non-typhoid serotypes]
Abstract
An example of evolutive engineering in bacterial pathogens is the emergence of hybrid virulence-resistance (VR) plasmids in Salmonella enterica, resulting from an association between antimicrobial resistance determinants and specific virulence plasmids of the S. typhimurium and S. choleraesuis serotypes. VR plasmids all possess the spv (Salmonella plasmid virulence) operon, which is involved in systemic infection; however, they differ in the presence of other virulence determinants and in the resistance gene profile. VR plasmids of S. typhimurium have been found in Europe, and show resistance regions with different levels of complexity that can include class 1 integrons and various transposons. VR plasmids of S. choleraesuis, detected in strains isolated in Taiwan, only confer resistance to ampicillin and sulfonamides. Both serotypes are zoonotic and the presence of hybrid VR plasmids may confer an adaptive advantage under certain conditions, resulting in bacterial strains that are more difficult to treat and have a higher epidemic potential.
Similar articles
-
Differences in the carriage and the ability to utilize the serotype associated virulence plasmid in strains of Salmonella enterica serotype Typhimurium investigated by use of a self-transferable virulence plasmid, pOG669.Microb Pathog. 2004 Jun;36(6):337-47. doi: 10.1016/j.micpath.2004.02.005. Microb Pathog. 2004. PMID: 15120160
-
Salmonella enterica serotype Typhimurium carrying hybrid virulence-resistance plasmids (pUO-StVR): a new multidrug-resistant group endemic in Spain.Int J Med Microbiol. 2008 Apr;298(3-4):253-61. doi: 10.1016/j.ijmm.2007.04.008. Epub 2007 Jun 26. Int J Med Microbiol. 2008. PMID: 17597002
-
Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUO-StVR2.J Antimicrob Chemother. 2006 Jan;57(1):39-45. doi: 10.1093/jac/dki400. Epub 2005 Nov 12. J Antimicrob Chemother. 2006. PMID: 16286360
-
Evolution of the virulence plasmids of non-typhoid Salmonella and its association with antimicrobial resistance.Microbes Infect. 2006 Jun;8(7):1931-6. doi: 10.1016/j.micinf.2005.12.026. Epub 2006 Mar 27. Microbes Infect. 2006. PMID: 16713725 Review.
-
Food animal-associated Salmonella challenges: pathogenicity and antimicrobial resistance.J Anim Sci. 2008 Apr;86(14 Suppl):E173-87. doi: 10.2527/jas.2007-0447. Epub 2007 Sep 18. J Anim Sci. 2008. PMID: 17878285 Review.
Cited by
-
Copy Number Heterogeneity in the Virulence Plasmid of Salmonella enterica.Front Microbiol. 2020 Dec 4;11:599931. doi: 10.3389/fmicb.2020.599931. eCollection 2020. Front Microbiol. 2020. PMID: 33343541 Free PMC article.
-
Prevalence of drug resistance and virulence features in Salmonella spp. isolated from foods associated or not with salmonellosis in Brazil.Rev Inst Med Trop Sao Paulo. 2014 Nov-Dec;56(6):461-7. doi: 10.1590/s0036-46652014000600001. Rev Inst Med Trop Sao Paulo. 2014. PMID: 25351537 Free PMC article.
-
Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain.Int J Mol Sci. 2014 Aug 15;15(8):14191-219. doi: 10.3390/ijms150814191. Int J Mol Sci. 2014. PMID: 25196519 Free PMC article.
-
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Clin Microbiol Rev. 2013 Apr;26(2):185-230. doi: 10.1128/CMR.00059-12. Clin Microbiol Rev. 2013. PMID: 23554414 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
