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Review
. 2009 Feb;10(2):94-108.
doi: 10.1038/nrg2504.

Small silencing RNAs: an expanding universe

Megha Ghildiyal  1 , Phillip D Zamore
Affiliations
Review

Small silencing RNAs: an expanding universe

Megha Ghildiyal et al. Nat Rev Genet. 2009 Feb.

Abstract

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). These classes differ in their biogenesis, their modes of target regulation and in the biological pathways they regulate. There is a growing realization that, despite their differences, these distinct small RNA pathways are interconnected, and that small RNA pathways compete and collaborate as they regulate genes and protect the genome from external and internal threats.

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References

    1. Fire A, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806–811. - PubMed
    1. Voinnet O. Non-cell autonomous RNA silencing. FEBS Lett. 2005;579:5858–5871. - PubMed
    1. Grishok A, Tabara H, Mello CC. Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000;287:2494–2497. - PubMed
    1. Hamilton AJ, Baulcombe DC. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science. 1999;286:950–952. - PubMed
    1. Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 2000;101:25–33. - PubMed

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