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Review
. 2009;29(2):73-8.
doi: 10.2165/0044011-200929020-00001.

Added benefits and user satisfaction with a low-dose oral contraceptive containing drospirenone: results of three multicentre trials

Johannes Bitzer  1 , Anna M Paoletti
Affiliations
Review

Added benefits and user satisfaction with a low-dose oral contraceptive containing drospirenone: results of three multicentre trials

Johannes Bitzer et al. Clin Drug Investig. 2009.

Abstract

The ethinylestradiol 20 microg/drospirenone 3 mg combined oral contraceptive (COC), administered in cycles of 21 days continuous use followed by a 7-day hormone-free interval (21/7) [Yasminelle], has been proven to be an effective and well tolerated contraceptive with an acceptable bleeding pattern and good safety profile. In addition, the ethinylestradiol 20 microg/drospirenone 3 mg 21/7 COC prevents water-retention-related weight gain, and improves physical and emotional well-being, consistent with other drospirenone-containing COCs. In clinical studies, >85% of those who received the ethinylestradiol 20 microg/drospirenone 3 mg 21/7 COC were satisfied or very satisfied with this contraceptive. The positive attributes of the ethinylestradiol 20 microg/drospirenone 3 mg 21/7 COC beyond contraceptive protection may have important implications for improving treatment compliance and reducing treatment discontinuation. Physical well-being stayed the same or improved during use of this COC in 56% and 34% of women, respectively. Emotional well-being stayed the same or improved in 71% and 20% of women, respectively.

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