Methylation and deamination of CpGs generate p53-binding sites on a genomic scale
- PMID: 19101055
- DOI: 10.1016/j.tig.2008.11.005
Methylation and deamination of CpGs generate p53-binding sites on a genomic scale
Abstract
The formation of transcription-factor-binding sites is an important evolutionary process. Here, we show that methylation and deamination of CpG dinucleotides generate in vivo p53-binding sites in numerous Alu elements and in non-repetitive DNA in a species-specific manner. In light of this, we propose that the deamination of methylated CpGs constitutes a universal mechanism for de novo generation of various transcription-factor-binding sites in Alus.
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