Cardioprotective actions of grape polyphenols
- PMID: 19083481
- DOI: 10.1016/j.nutres.2008.08.007
Cardioprotective actions of grape polyphenols
Abstract
The aim of this review is to discuss the accumulating evidence that suggests that grape extracts and purified grape polyphenols possess a diverse array of biological actions and may be beneficial in the prevention of some inflammatory-mediated diseases including cardiovascular disease. The active components from grape extracts, which include the grape seed, grape skin, and grape juice, that have been identified thus far include polyphenols such as resveratrol, phenolic acids, anthocyanins, and flavonoids. All possess potent antioxidant properties and have been shown to decrease low-density lipoprotein-cholesterol oxidation and platelet aggregation. These compounds also possess a range of additional cardioprotective and vasoprotective properties including antiatherosclerotic, antiarrhythmic, and vasorelaxation actions. Although not exclusive, antioxidant properties of grape polyphenols are likely to be central to their mechanism(s) of action, which also include cellular signaling mechanisms and interactions at the genomic level. This review discusses some of the evidence favoring the consumption of grape extracts rich in polyphenols in the prevention of cardiovascular disease. Consumption of grape and grape extracts and/or grape products such as red wine may be beneficial in preventing the development of chronic degenerative diseases such as cardiovascular disease.
Similar articles
-
Grape products and cardiovascular disease risk factors.Nutr Res Rev. 2008 Dec;21(2):158-73. doi: 10.1017/S0954422408125124. Nutr Res Rev. 2008. PMID: 19087369 Review.
-
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.Nutr Res. 2008 Dec;28(12):842-50. doi: 10.1016/j.nutres.2008.09.001. Epub 2008 Nov 8. Nutr Res. 2008. PMID: 19083497
-
Recent applications of grape polyphenols in foods, beverages and supplements.Recent Pat Food Nutr Agric. 2010 Jun;2(2):105-9. Recent Pat Food Nutr Agric. 2010. PMID: 20653555 Review.
-
Total phenolic contents and free-radical scavenging activities of grape (Vitis vinifera L.) and grape products.Int J Food Sci Nutr. 2013 Mar;64(2):210-6. doi: 10.3109/09637486.2012.728199. Epub 2012 Oct 2. Int J Food Sci Nutr. 2013. PMID: 23025419
-
Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process.J Hypertens. 2007 Mar;25(3):541-9. doi: 10.1097/HJH.0b013e328013e805. J Hypertens. 2007. PMID: 17278969
Cited by
-
Secondary Metabolites of Plants as Modulators of Endothelium Functions.Int J Mol Sci. 2021 Mar 3;22(5):2533. doi: 10.3390/ijms22052533. Int J Mol Sci. 2021. PMID: 33802468 Free PMC article. Review.
-
Therapeutic and Nutraceutical Effects of Polyphenolics from Natural Sources.Molecules. 2022 Sep 22;27(19):6225. doi: 10.3390/molecules27196225. Molecules. 2022. PMID: 36234762 Free PMC article. Review.
-
Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.PLoS One. 2012;7(9):e45997. doi: 10.1371/journal.pone.0045997. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23049918 Free PMC article.
-
Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Cagnulari Grape Pomace on Oxidative Endothelial Cell Death.Molecules. 2018 Aug 21;23(9):2105. doi: 10.3390/molecules23092105. Molecules. 2018. PMID: 30134642 Free PMC article.
-
Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner.Cardiovasc Res. 2011 Apr 1;90(1):140-7. doi: 10.1093/cvr/cvq355. Epub 2010 Nov 10. Cardiovasc Res. 2011. PMID: 21071431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
