Review
doi: 10.1038/mi.2008.43.
CD103+ GALT DCs promote Foxp3+ regulatory T cells
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- PMID: 19079226
- DOI: 10.1038/mi.2008.43
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Review
CD103+ GALT DCs promote Foxp3+ regulatory T cells
Mucosal Immunol.
2008 Nov.
Free article
Abstract
There is evidence that Foxp3(+) regulatory T (T(R)) cells contribute to intestinal homeostasis and that deficiencies in this population can lead to chronic intestinal inflammation. Here, we review recent studies that demonstrate that the gut is a site of peripheral generation of T(R) cells. Functionally specialized gut dendritic cell populations promote T(R) cells through a transforming growth factor-beta and retinoic acid-dependent mechanism. Gut-driven T(R) cells may represent a tissue-specific mechanism to broaden the repertoire of T(R) cells focussed on the gut.
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