Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan;9(1):15-27.
doi: 10.1038/nrc2542. Epub 2008 Dec 11.

The biology of Hodgkin's lymphoma

Ralf Küppers  1
Affiliations
Review

The biology of Hodgkin's lymphoma

Ralf Küppers. Nat Rev Cancer. 2009 Jan.

Abstract

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent genetic lesions. The pathogenetic role for Epstein-Barr virus infection has also been substantiated. HRS cells in classical Hodgkin's lymphoma have several characteristics that are unusual for lymphoid tumour cells, and the Hodgkin's lymphoma microenvironment is dominated by an extensive mixed, potentially inflammatory cellular infiltrate. Understanding the contribution of all of these changes to the pathogenesis of this disease is essential for the development of novel therapies.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Blood. 2008 Jan 1;111(1):292-301 - PubMed
    1. N Engl J Med. 1999 Apr 22;340(16):1239-47 - PubMed
    1. Am J Pathol. 1995 Oct;147(4):912-22 - PubMed
    1. Blood. 2005 Dec 15;106(13):4249-52 - PubMed
    1. Cancer Res. 2001 Mar 1;61(5):2080-4 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources