[Identification and localization on chromosome 1 of a gene controlling the occurrence of periinsulitis in NOD diabetic mice]
[Article in
French]
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- PMID: 1905182
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[Identification and localization on chromosome 1 of a gene controlling the occurrence of periinsulitis in NOD diabetic mice]
[Article in
French]
C R Acad Sci III.
1991.
Abstract
Diabetic NOD (Non Obese Diabetic) mice show early pancreatic infiltration of mononuclear cells around Langerhans islets (periinsulitis). Study of (NOD x C57BL/6) F1 and F2 mice reveals that periinsulitis is constantly associated with a similar infiltration of salivary glands (sialitis) and is controlled by a dominant susceptibility locus. Segregation analysis of periinsulitis and microsatellite DNA markers indicates that the gene controlling periinsulitis maps to chromosome 1, close to the Bcl-2 locus.
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