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. 2008 Oct 1:11:4.
doi: 10.1186/1758-2652-11-4.

Prevention of the sexual transmission of HIV-1: preparing for success

Myron S Cohen  1 , Pontiano Kaleebu, Thomas Coates
Affiliations

Prevention of the sexual transmission of HIV-1: preparing for success

Myron S Cohen et al. J Int AIDS Soc. .

Abstract

There are four opportunities for HIV prevention: before exposure, at the moment of exposure, immediately after exposure, and as secondary prevention focused on infected subjects. Until recently, most resources have been directed toward behavioral strategies aimed at preventing exposure entirely. Recognizing that these strategies are not enough to contain the epidemic, investigators are turning their attention to post-exposure prevention opportunities. There is increasing focus on the use of ART-either systemic or topical (microbicides)-to prevent infection at the moment of exposure. Likewise, there is growing evidence that ART treatment of infected people could serve as prevention as well. A number of ongoing clinical trials will shed some light on the potential of these approaches. Above all, prevention of HIV requires decision-makers to focus resources on strategies that are most effective. Finally, treatment of HIV and prevention of HIV must be considered and deployed together.

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Figures

Figure 1
Figure 1
HIV Prevention opportunities, adapted from[4].
Figure 2
Figure 2
Infectiousness and susceptibility, adapted from[16].
Figure 3
Figure 3
HIV-1 Transmission Event, adapted from[25].
Figure 4
Figure 4
Male and Female GT ART, reproduced with permission from[46].
See this image and copyright information in PMC

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References

    1. UNAIDS. AIDS Epidemic Update. Vol. 11. Geneva, Switzerland: UNAIDS; 2007.
    1. Potts M, Halperin DT, Kirby D, Swidler A, Marseille E, Klausner JD, Hearst N, Wamai RG, Kahn JG, Walsh J. Public health. Reassessing HIV prevention. Science. 2008;11(5877):749–750. doi: 10.1126/science.1153843. - DOI - PMC - PubMed
    1. Coates TJ, Richter L, Caceres C. Behavioural strategies to reduce HIV transmission: what will make them work better? Lancet. 2008. in press . - PMC - PubMed
    1. Cohen MS, Hellmann N, Levy JA, DeCock K, Lange J. The spread, treatment, and prevention of HIV-1: evolution of a global pandemic. J Clin Invest. 2008;11(4):1244–1254. doi: 10.1172/JCI34706. - DOI - PMC - PubMed
    1. Sepulveda J, Carpenter C, Curran J, Holzemer W, Smits H, Scott K, Orza M. PEPFAR Implementation: Progress and Promise. Washington, D.C.: National Academies Press; 2007.

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