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. 2008 Oct 31;40(5):558-64.
doi: 10.3858/emm.2008.40.5.558.

Heritability and linkage study on heart rates in a Mongolian population

Bayasgalan Gombojav  1 , Hansoo Park, Jong Il Kim, Young Seok Ju, Joohon Sung, Sung Il Cho, Mi Kyeong Lee, Heechoul Ohrr, Janchiv Radnaabazar, Jeong Sun Seo
Affiliations

Heritability and linkage study on heart rates in a Mongolian population

Bayasgalan Gombojav et al. Exp Mol Med. .

Abstract

Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P<.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.

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Figures

Figure 1
Figure 1
Genome-wide linkage analysis of chromosomal regions linked to heart rate.
Figure 2
Figure 2
Evidence of linkage (LOD score = 2.03) of a quantitative trait locus (QTL) for heart rate on chromosomes 18 at 77 cM.
See this image and copyright information in PMC

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