The North American Immune Tolerance Registry: contributions to the thirty-year experience with immune tolerance therapy
- PMID: 18976249
- DOI: 10.1111/j.1365-2516.2008.01880.x
The North American Immune Tolerance Registry: contributions to the thirty-year experience with immune tolerance therapy
Abstract
The North American Immune Tolerance Registry (NAITR) began in 1992 as a project of the ISTH Factor VIII/IX Subcommittee with the goal of further determining immune tolerance induction (ITI) practices in Canada and the United States. This retrospective registry study, published in 2002, was limited in its capacity to provide definitive answers to many unresolved ITI practice issues. Nonetheless, it played a role in developing guidelines for current ITI practice and in generating hypotheses that must now be examined through rigorous prospective data collection efforts. For haemophilia A, the logical next step has been the initiation of international prospective randomized studies of ITI outcome relative to factor VIII (FVIII) dose and purity for subjects with high titre inhibitors. Both trials will additionally provide platforms for translational study of the immunology of tolerance, a prelude to the next generation of safe and effective tolerizing strategies. For the less common problem of FIX inhibitor eradication, prospective randomized studies will not be a feasible way to confirm the NAITR observations. Coordinated international efforts will still be required to prospectively collect data on ITI outcome to document new potentially effective therapeutic strategies for inhibitor eradication. These registries will hopefully also serve to identify potential subjects for scientific studies of immunology of haemophilia B-related allergic phenomena, a devastating complication of FIX antibody development.
Similar articles
-
Immune tolerance: critical issues of factor dose, purity and treatment complications.Haemophilia. 2006 Dec;12 Suppl 6:81-5; discussion 85-6. doi: 10.1111/j.1365-2516.2006.01376.x. Haemophilia. 2006. PMID: 17123399 Review.
-
The maintenance of tolerance after successful immune tolerance induction in hemophilia A and B: the North American Registry. Factor VIII/IX Subcommittee of the International Society for Thrombosis and Hemostasis.Haematologica. 2000 Oct;85(10 Suppl):40-2; discussion 42-4. Haematologica. 2000. PMID: 11187869
-
The North American Immune Tolerance Registry: practices, outcomes, outcome predictors.Thromb Haemost. 2002 Jan;87(1):52-7. Thromb Haemost. 2002. PMID: 11848456
-
The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation.Br J Haematol. 2006 Jun;133(6):591-605. doi: 10.1111/j.1365-2141.2006.06087.x. Br J Haematol. 2006. PMID: 16704433 Review.
-
Immune tolerance in haemophilia: the long journey to the fork in the road.Br J Haematol. 2012 Oct;159(2):123-34. doi: 10.1111/bjh.12028. Epub 2012 Aug 28. Br J Haematol. 2012. PMID: 22924753 Review.
Cited by
-
Gene therapy for immune tolerance induction in hemophilia with inhibitors.J Thromb Haemost. 2016 Jun;14(6):1121-34. doi: 10.1111/jth.13331. Epub 2016 May 14. J Thromb Haemost. 2016. PMID: 27061380 Free PMC article. Review.
-
Immune tolerance induction for treating inhibitors in people with congenital haemophilia A or B.Cochrane Database Syst Rev. 2014 Apr 24;2014(4):CD010561. doi: 10.1002/14651858.CD010561.pub2. Cochrane Database Syst Rev. 2014. PMID: 24763974 Free PMC article. Review.
-
A survey of applications of biological products for drug interference of immunogenicity assays.Pharm Res. 2012 Dec;29(12):3384-92. doi: 10.1007/s11095-012-0833-2. Epub 2012 Aug 18. Pharm Res. 2012. PMID: 22903525
-
Recurrent episodes of anaphylaxis in a patient with haemophilia B: a case report.Blood Transfus. 2016 Nov;14(6):582-584. doi: 10.2450/2016.0297-15. Epub 2016 Apr 28. Blood Transfus. 2016. PMID: 27177407 Free PMC article. No abstract available.
-
Treatment and Prevention of Bleeds in Haemophilia Patients with Inhibitors to Factor VIII/IX.J Clin Med. 2017 Apr 17;6(4):46. doi: 10.3390/jcm6040046. J Clin Med. 2017. PMID: 28420167 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
