Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex
- PMID: 18957210
- DOI: 10.1016/j.neuron.2008.10.009
Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex
Abstract
Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic "inside out" lamination pattern. In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the effects of Reelin on neuronal cell migration.
Comment on
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Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.Neuron. 2008 Oct 23;60(2):273-84. doi: 10.1016/j.neuron.2008.09.026. Neuron. 2008. PMID: 18957219 Free PMC article.
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