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Review
. 2008 Oct;9(10):747-58.
doi: 10.1038/nrm2509.

The RSK family of kinases: emerging roles in cellular signalling

Rana Anjum  1 , John Blenis
Affiliations
Review

The RSK family of kinases: emerging roles in cellular signalling

Rana Anjum et al. Nat Rev Mol Cell Biol. 2008 Oct.

Abstract

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. Significant advances in the field of RSK and ERK/MAPK signalling have occurred in the past few years, including biological insights and the discovery of novel substrates and new RSK regulatory mechanisms. Collectively, these data expand the current models of RSK signalling and highlight potential directions of research in RSK-mediated survival, growth, proliferation and migration.

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