From yeast killer toxins to antibiobodies and beyond
- PMID: 18785931
- DOI: 10.1111/j.1574-6968.2008.01340.x
From yeast killer toxins to antibiobodies and beyond
Abstract
Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. The perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.
Similar articles
-
Therapeutic potential of yeast killer toxin-like antibodies and mimotopes.FEMS Yeast Res. 2004 Oct;5(1):11-8. doi: 10.1016/j.femsyr.2004.06.010. FEMS Yeast Res. 2004. PMID: 15381118 Review.
-
Killer anti-idiotypes in the control of fungal infections.Curr Opin Investig Drugs. 2001 Apr;2(4):477-9. Curr Opin Investig Drugs. 2001. PMID: 11566002 Review.
-
From Pichia anomala killer toxin through killer antibodies to killer peptides for a comprehensive anti-infective strategy.Antonie Van Leeuwenhoek. 2011 Jan;99(1):35-41. doi: 10.1007/s10482-010-9496-3. Epub 2010 Aug 18. Antonie Van Leeuwenhoek. 2011. PMID: 20714805
-
Effect of a killer toxin of Pichia anomala to Pneumocystis. Perspectives in the control of pneumocystosis.FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):145-9. doi: 10.1111/j.1574-695X.1998.tb01199.x. FEMS Immunol Med Microbiol. 1998. PMID: 9792073 Review.
-
In vitro activity of a monoclonal killer anti-idiotypic antibody and a synthetic killer peptide against oral isolates of Candida spp. differently susceptible to conventional antifungals.Oral Microbiol Immunol. 2005 Aug;20(4):226-32. doi: 10.1111/j.1399-302X.2005.00217.x. Oral Microbiol Immunol. 2005. PMID: 15943767
Cited by
-
Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells.Transl Oncol. 2010 Aug 1;3(4):204-17. doi: 10.1593/tlo.09316. Transl Oncol. 2010. PMID: 20689762 Free PMC article.
-
Disruption of the gene encoding β-1, 3-glucanase in marine-derived Williopsis saturnus WC91-2 enhances its killer toxin activity.Mar Biotechnol (NY). 2012 Jun;14(3):261-9. doi: 10.1007/s10126-011-9409-0. Epub 2011 Oct 8. Mar Biotechnol (NY). 2012. PMID: 21984025
-
In Vitro and In Vivo Anti-Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives.J Fungi (Basel). 2021 Feb 10;7(2):129. doi: 10.3390/jof7020129. J Fungi (Basel). 2021. PMID: 33578728 Free PMC article.
-
Antibodies as an unlimited source of anti-infective, anti-tumour and immunomodulatory peptides.Sci Prog. 2014;97(Pt 3):215-33. doi: 10.3184/003685014X14049273183515. Sci Prog. 2014. PMID: 25549407 Free PMC article. Review.
-
Molecular Basis of Yeasts Antimicrobial Activity-Developing Innovative Strategies for Biomedicine and Biocontrol.Curr Issues Mol Biol. 2024 May 14;46(5):4721-4750. doi: 10.3390/cimb46050285. Curr Issues Mol Biol. 2024. PMID: 38785553 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
