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Review
. 2008 Aug 14;14(30):4721-4.
doi: 10.3748/wjg.14.4721.

Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors

Carl C Schimanski  1 , Peter R Galle, Markus Moehler
Affiliations
Review

Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors

Carl C Schimanski et al. World J Gastroenterol. .

Abstract

To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta". CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1alpha might act as "chemorepellent" while SDF-1beta might act as "chemorepellent" for CTLs, inducing tumor rejection. The paracrine expression of SDF-1alpha was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of CXCR4 might be an interesting therapeutic option.

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Figures

Figure 1
Figure 1
CXCR4 mediates tumor dissemination via induction of tumor cell migration and invasion and via stimulation of neoangiogenesis. The CXCR4 ligand SDF-1α might act as “chemorepellent” preventing tumor rejection.
See this image and copyright information in PMC

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