doi: 10.1016/j.febslet.2008.07.027.
Epub 2008 Jul 24.
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
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- PMID: 18656473
- DOI: 10.1016/j.febslet.2008.07.027
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Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
FEBS Lett.
.
Free article
Abstract
A monoclonal antibody specific for phosphoserines 409 and 410 of TDP-43 (mAb pS409/410) has been produced. It strongly stained TDP-43-positive inclusions in brain of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, but did not stain nuclei, in which normal TDP-43 is localized. It did not recognize TDP-43 rapidly extracted from brains of rats at various developmental stages, strongly suggesting that phosphorylation of Ser409/410 is an abnormal event. Analysis of postmortem changes of TDP-43 revealed that the amounts of Sarkosyl-insoluble, urea-soluble full-length TDP-43 and a 35kDa N-terminal fragment increased time-dependently.
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