Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
- PMID: 18656387
- DOI: 10.1016/j.immuni.2008.05.014
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
Abstract
Immunoglobulin A (IgA) is generated in the gut by both T cell-dependent and T cell-independent processes. The sites and the mechanisms for T cell-independent IgA synthesis remain elusive. Here we show that isolated lymphoid follicles (ILFs) were sites where induction of activation-induced cytidine deaminase (AID) and IgA class switching of B cells took place in the absence of T cells. We also show that formation of ILFs was regulated by interactions between lymphoid tissue-inducer cells expressing the nuclear receptor ROR gamma t (ROR gamma t(+)LTi cells) and stromal cells (SCs). Activation of SCs by ROR gamma t(+)LTi cells through lymphotoxin (LT)-beta receptor (LT beta R) and simultaneously by bacteria through TLRs induced recruitment of dendritic cells (DCs) and B cells and formation of ILFs. These findings provide insight into the crosstalk between bacteria, ROR gamma t(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut.
Comment in
-
The architects of B and T cell immune responses.Immunity. 2008 Aug 15;29(2):171-2. doi: 10.1016/j.immuni.2008.07.005. Immunity. 2008. PMID: 18701078
Similar articles
-
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.J Immunol. 2009 Aug 15;183(4):2217-21. doi: 10.4049/jimmunol.0802911. Epub 2009 Jul 27. J Immunol. 2009. PMID: 19635901
-
How host-bacterial interactions lead to IgA synthesis in the gut.Trends Immunol. 2008 Nov;29(11):523-31. doi: 10.1016/j.it.2008.08.001. Trends Immunol. 2008. PMID: 18838301 Review.
-
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.Nature. 2007 Aug 23;448(7156):929-33. doi: 10.1038/nature06033. Nature. 2007. PMID: 17713535
-
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.Science. 2002 Nov 15;298(5597):1424-7. doi: 10.1126/science.1077336. Science. 2002. PMID: 12434060
-
Interactions of commensal gut microbes with subsets of B- and T-cells in the murine host.Vaccine. 2004 Feb 17;22(7):805-11. doi: 10.1016/j.vaccine.2003.11.022. Vaccine. 2004. PMID: 15040931 Review.
Cited by
-
Small Intestinal Goblet Cells Control Humoral Immune Responses and Mobilization During Enteric Infection.bioRxiv [Preprint]. 2024 Jan 7:2024.01.06.573891. doi: 10.1101/2024.01.06.573891. bioRxiv. 2024. PMID: 38260555 Free PMC article. Preprint.
-
Microbial-immune cross-talk and regulation of the immune system.Immunology. 2013 Jan;138(1):12-22. doi: 10.1111/j.1365-2567.2012.03624.x. Immunology. 2013. PMID: 22804726 Free PMC article. Review.
-
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.Genes Immun. 2015 Apr-May;16(3):177-86. doi: 10.1038/gene.2014.83. Epub 2015 Jan 22. Genes Immun. 2015. PMID: 25611557 Free PMC article. Review.
-
The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease.Front Immunol. 2023 Oct 2;14:1260266. doi: 10.3389/fimmu.2023.1260266. eCollection 2023. Front Immunol. 2023. PMID: 37849749 Free PMC article. Review.
-
Intestinal IgA production and its role in host-microbe interaction.Immunol Rev. 2014 Jul;260(1):76-85. doi: 10.1111/imr.12189. Immunol Rev. 2014. PMID: 24942683 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous