Comment
doi: 10.1038/ncb0708-757.
Breaking down EMT
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- PMID: 18591967
- DOI: 10.1038/ncb0708-757
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Comment
Breaking down EMT
Nat Cell Biol.
2008 Jul.
Abstract
Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.
Comment on
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RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation.Nat Cell Biol. 2008 Jul;10(7):765-75. doi: 10.1038/ncb1739. Epub 2008 Jun 15. Nat Cell Biol. 2008. PMID: 18552836
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