Synthetic antimicrobial peptidomimetics with therapeutic potential
- PMID: 18570363
- DOI: 10.1021/jm701600a
Synthetic antimicrobial peptidomimetics with therapeutic potential
Abstract
A series of synthetic antimicrobial peptidomimetics (SAMPs) have been prepared and found to be highly active against several Gram-negative and Gram-positive bacterial strains. These derivatives comprise the minimal structural requirements for cationic antimicrobial peptides and showed high selectivity for Gram-negative and/or Gram-positive bacteria compared to human red blood cells. We have found that SAMPs share many of the attractive properties of cationic antimicrobial peptides inasmuch that a representative SAMP was found to insert into the bilayers of large unilamellar vesicles, permeabilized both the outer and cytoplasmic membrane of Escherichia coli ML-35p, and displayed an extremely rapid bacterial killing for Staphylococcus aureus. However, while antimicrobial peptides are prone to proteolytic degradation, high in vitro stability in human blood plasma was shown for SAMPs. A combination of high antibacterial activity against methicillin-resistant staphylococci and low toxicity against human erythrocytes makes these molecules promising candidates for novel antibacterial therapeutics.
Similar articles
-
A novel polycationic analogue of gratisin with antibiotic activity against both Gram-positive and Gram-negative bacteria.J Antibiot (Tokyo). 2008 Jan;61(1):33-5. doi: 10.1038/ja.2008.106. J Antibiot (Tokyo). 2008. PMID: 18305357
-
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.Int J Antimicrob Agents. 2008 Aug;32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003. Epub 2008 Jun 30. Int J Antimicrob Agents. 2008. PMID: 18586467
-
Ceragenins: cholic acid-based mimics of antimicrobial peptides.Acc Chem Res. 2008 Oct;41(10):1233-40. doi: 10.1021/ar700270t. Epub 2008 Jul 11. Acc Chem Res. 2008. PMID: 18616297
-
Antimicrobial AApeptides.Curr Top Med Chem. 2017;17(11):1266-1279. doi: 10.2174/1568026616666161018145945. Curr Top Med Chem. 2017. PMID: 27758686 Free PMC article. Review.
-
Antimicrobial peptides: promising alternatives to conventional antibiotics.J Mol Microbiol Biotechnol. 2011;20(4):228-35. doi: 10.1159/000331009. Epub 2011 Sep 2. J Mol Microbiol Biotechnol. 2011. PMID: 21894027 Review.
Cited by
-
Therapeutic potential of HIV-1 entry inhibitor peptidomimetics.Exp Biol Med (Maywood). 2021 May;246(9):1060-1068. doi: 10.1177/1535370221990870. Epub 2021 Feb 17. Exp Biol Med (Maywood). 2021. PMID: 33596698 Free PMC article. Review.
-
Advances in the Study of Structural Modification and Biological Activities of Anoplin.Front Chem. 2020 Jul 7;8:519. doi: 10.3389/fchem.2020.00519. eCollection 2020. Front Chem. 2020. PMID: 32733845 Free PMC article. Review.
-
Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling.Org Lett. 2013 Jan 18;15(2):362-5. doi: 10.1021/ol303314x. Epub 2012 Dec 26. Org Lett. 2013. PMID: 23268775 Free PMC article.
-
Small AntiMicrobial Peptide With in Vivo Activity Against Sepsis.Molecules. 2019 May 1;24(9):1702. doi: 10.3390/molecules24091702. Molecules. 2019. PMID: 31052373 Free PMC article.
-
Review: Structure-Activity Relationship of Antimicrobial Peptoids.Pharmaceutics. 2023 May 15;15(5):1506. doi: 10.3390/pharmaceutics15051506. Pharmaceutics. 2023. PMID: 37242748 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
