Point-of-care testing for malaria outbreak management
- PMID: 18513771
- DOI: 10.1016/j.trstmh.2008.04.018
Point-of-care testing for malaria outbreak management
Abstract
A rapid antigen assay for malaria was performed on blood samples collected during a simultaneous outbreak of falciparum malaria and vivax malaria on a remote island in the Indonesian archipelago. During the outbreak, a total of 89 patients (4.3% of the population) were diagnosed with malaria within a week. Microscopic examination revealed 78 malaria slide-positive cases, of whom 49 (62.8%) were identified as P. falciparum, 7 (9.0%) as P. vivax and 22 (28.2%) as mixed P. falciparum and P. vivax infections. The rapid malaria assay showed excellent correlation with expert-confirmed routine microscopy for P. falciparum and P. vivax monoinfections and mixed infections with a parasite density >50 parasites/microl. Several slide-negative blood samples collected from febrile patients with clinical malaria tested positive in the rapid test. The estimated sensitivity calculated for the rapid test (91.0%) was slightly higher than that of microscopy (87.6%). The result indicates that rapid antigen detection for malaria could be a useful alternative to microscopy to reduce the workload during emergency outbreak situations.
Comment in
-
Comment on: Point-of-care testing for malaria outbreak management.Trans R Soc Trop Med Hyg. 2009 Jan;103(1):106; author reply 106. doi: 10.1016/j.trstmh.2008.07.006. Epub 2008 Aug 28. Trans R Soc Trop Med Hyg. 2009. PMID: 18760434 No abstract available.
Similar articles
-
Evaluation of a rapid diagnostic test specific for Plasmodium vivax.Trop Med Int Health. 2008 Dec;13(12):1495-500. doi: 10.1111/j.1365-3156.2008.02163.x. Epub 2008 Oct 6. Trop Med Int Health. 2008. PMID: 18983278
-
Rapid immunochromatography-based detection of mixed-species malaria infection in Pakistan.Southeast Asian J Trop Med Public Health. 2005 May;36(3):562-4. Southeast Asian J Trop Med Public Health. 2005. PMID: 16124417
-
Rapid diagnostic devices for malaria: field evaluation of a new prototype immunochromatographic assay for the detection of Plasmodium falciparum and non-falciparum Plasmodium.Am J Trop Med Hyg. 2003 Jul;69(1):26-30. Am J Trop Med Hyg. 2003. PMID: 12932092
-
Antibody detection ELISAS for malaria diagnosis.Southeast Asian J Trop Med Public Health. 1992 Dec;23(4):752-61. Southeast Asian J Trop Med Public Health. 1992. PMID: 1298085 Review.
-
Review and recent progress: the mathematical modeling of mixed species Plasmodium infections.Southeast Asian J Trop Med Public Health. 2000;31 Suppl 1:69-74. Southeast Asian J Trop Med Public Health. 2000. PMID: 11414463 Review.
Cited by
-
Mitochondrial DNA targets increase sensitivity of malaria detection using loop-mediated isothermal amplification.J Clin Microbiol. 2010 Aug;48(8):2866-71. doi: 10.1128/JCM.00355-10. Epub 2010 Jun 16. J Clin Microbiol. 2010. PMID: 20554824 Free PMC article.
-
Emerging nucleic acid-based tests for point-of-care detection of malaria.Am J Trop Med Hyg. 2012 Aug;87(2):223-230. doi: 10.4269/ajtmh.2012.11-0685. Am J Trop Med Hyg. 2012. PMID: 22855751 Free PMC article. Review.
-
Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries.Cochrane Database Syst Rev. 2014 Dec 18;2014(12):CD011431. doi: 10.1002/14651858.CD011431. Cochrane Database Syst Rev. 2014. PMID: 25519857 Free PMC article. Review.
-
Summary of discordant results between rapid diagnosis tests, microscopy, and polymerase chain reaction for detecting Plasmodium mixed infection: a systematic review and meta-analysis.Sci Rep. 2020 Jul 29;10(1):12765. doi: 10.1038/s41598-020-69647-y. Sci Rep. 2020. PMID: 32728145 Free PMC article.
-
Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries.Cochrane Database Syst Rev. 2011 Jul 6;2011(7):CD008122. doi: 10.1002/14651858.CD008122.pub2. Cochrane Database Syst Rev. 2011. PMID: 21735422 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
