Antibody to a hepatitis C virus related protein among patients at high risk for hepatitis B
- PMID: 1851322
- DOI: 10.3109/00365549109023369
Antibody to a hepatitis C virus related protein among patients at high risk for hepatitis B
Abstract
Anti-HCV prevalence in treated hemophiliacs, their heterosexual partners, intravenous drug addicts and homosexual men was studied. In hemophiliacs and many of the intravenous drug addicts, greater than or equal to 2 sera drawn 1-18 or 1-17 years apart were available. Anti-HCV testing was performed by ELISA (Ortho). Among patients with severe and moderate hemophilia A, 87% (98/112) were positive for anti-HCV at least once and among patients with severe and moderate hemophilia B, 83% (24/29) were positive for anti-HCV. Seroconversion to anti-HCV was observed in 21% of hemophilia patients. In hemophilia A, HCV infection generally occurred during the first years of life and in hemophilia B somewhat later. Loss of anti-HCV antibody was seen in 12% (17 patients). The rest, 54% (76 patients) were seropositive in first and last samples. All 12 tested spouses to anti-HCV positive men were anti-HCV negative. 80% of the drug addicts (137/172) were seropositive for anti-HCV. In those with greater than 1 serum tested, 8% were consistently negative and 68% consistently positive. 21% seroconverted to anti-HCV while 3% lost antibody. 10% (22/211) of homosexual men were anti-HCV positive. Intravenous transmission of HCV thus seemed highly efficient whereas sexual transmission was much less efficient.
Similar articles
-
Heterosexual and homosexual transmission of hepatitis C virus: relation with hepatitis B virus and human immunodeficiency virus type 1.Epidemiol Infect. 1991 Dec;107(3):667-72. doi: 10.1017/s0950268800049360. Epidemiol Infect. 1991. PMID: 1661241 Free PMC article.
-
Transmission of hepatitis C virus to sexual partners of seropositive patients with bleeding disorders: a rare event.Scand J Infect Dis. 1991;23(6):667-70. doi: 10.3109/00365549109024290. Scand J Infect Dis. 1991. PMID: 1667715
-
Search for intrafamilial transmission of hepatitis C virus in hemophilia patients.Blood. 1993 Feb 15;81(4):1077-82. Blood. 1993. PMID: 8381312
-
Hepatitis C infection in patients with hemophilia: results of a national survey. Canadian Hemophilia Clinic Directors Group.Transfus Med Rev. 1994 Jul;8(3):210-7. doi: 10.1016/s0887-7963(94)70112-7. Transfus Med Rev. 1994. PMID: 8081082 Review. No abstract available.
-
Importance of hepatitis C virus infection in Europe and North America.Curr Stud Hematol Blood Transfus. 1994;(61):164-81. doi: 10.1159/000423274. Curr Stud Hematol Blood Transfus. 1994. PMID: 7956328 Review. No abstract available.
Cited by
-
Prevalence of Hepatitis C virus antibody in patients with sexually transmitted diseases attending a Harrisburg, PA, STD clinic.Infect Dis Obstet Gynecol. 1994;1(6):269-74. doi: 10.1155/S1064744994000232. Infect Dis Obstet Gynecol. 1994. PMID: 18475350 Free PMC article.
-
Prevalence of antibodies to hepatitis C virus and association with intravenous drug abuse and tattooing in a national prison in Norway.Eur J Clin Microbiol Infect Dis. 1993 Sep;12(9):673-6. doi: 10.1007/BF02009378. Eur J Clin Microbiol Infect Dis. 1993. PMID: 7694850
-
Seroprevalence of cytomegalovirus, Toxoplasma gondii, syphilis, and hepatitis B and C virus infections in a regional population seropositive for HIV infection.Can J Infect Dis. 1998 Jul;9(4):209-14. doi: 10.1155/1998/380687. Can J Infect Dis. 1998. PMID: 22346544 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
