Review
doi: 10.1038/nrm2417.
Epub 2008 May 21.
Mechanisms of membrane fusion: disparate players and common principles
Affiliations
- PMID: 18496517
- DOI: 10.1038/nrm2417
Item in Clipboard
Review
Mechanisms of membrane fusion: disparate players and common principles
Nat Rev Mol Cell Biol.
2008 Jul.
Abstract
Membrane fusion can occur between cells, between different intracellular compartments, between intracellular compartments and the plasma membrane and between lipid-bound structures such as viral particles and cellular membranes. In order for membranes to fuse they must first be brought together. The more highly curved a membrane is, the more fusogenic it becomes. We discuss how proteins, including SNAREs, synaptotagmins and viral fusion proteins, might mediate close membrane apposition and induction of membrane curvature to drive diverse fusion processes. We also highlight common principles that can be derived from the analysis of the role of these proteins.
Similar articles
-
Synaptotagmin: fusogenic role for calcium sensor?Nat Struct Mol Biol. 2006 Apr;13(4):301-3. doi: 10.1038/nsmb0406-301. Nat Struct Mol Biol. 2006. PMID: 16715046 No abstract available.
-
Role of SNAREs in membrane fusion.Adv Exp Med Biol. 2011;713:13-32. doi: 10.1007/978-94-007-0763-4_3. Adv Exp Med Biol. 2011. PMID: 21432012 Review.
-
The role of transmembrane domains in membrane fusion.Cell Mol Life Sci. 2007 Apr;64(7-8):850-64. doi: 10.1007/s00018-007-6439-x. Cell Mol Life Sci. 2007. PMID: 17429580 Free PMC article. Review.
-
A continuum model of docking of synaptic vesicle to plasma membrane.J R Soc Interface. 2015 Jan 6;12(102):20141119. doi: 10.1098/rsif.2014.1119. J R Soc Interface. 2015. PMID: 25551140 Free PMC article.
-
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release.Trends Cell Biol. 2006 Jul;16(7):339-50. doi: 10.1016/j.tcb.2006.04.006. Epub 2006 May 12. Trends Cell Biol. 2006. PMID: 16698267 Review.
Cited by
-
Mechanism for calcium ion sensing by the C2A domain of synaptotagmin I.Biophys J. 2012 Jul 18;103(2):238-46. doi: 10.1016/j.bpj.2012.05.051. Epub 2012 Jul 17. Biophys J. 2012. PMID: 22853901 Free PMC article.
-
The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism.Biomolecules. 2020 Jul 21;10(7):1085. doi: 10.3390/biom10071085. Biomolecules. 2020. PMID: 32708307 Free PMC article.
-
On the ultrastructural organization of Trypanosoma cruzi using cryopreparation methods and electron tomography.Histochem Cell Biol. 2012 Dec;138(6):821-31. doi: 10.1007/s00418-012-1002-8. Epub 2012 Aug 8. Histochem Cell Biol. 2012. PMID: 22872316
-
A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion.J Cell Biol. 2023 Feb 6;222(2):e202207147. doi: 10.1083/jcb.202207147. Epub 2022 Nov 17. J Cell Biol. 2023. PMID: 36394541 Free PMC article.
-
How Myxobacteria Cooperate.J Mol Biol. 2015 Nov 20;427(23):3709-21. doi: 10.1016/j.jmb.2015.07.022. Epub 2015 Aug 5. J Mol Biol. 2015. PMID: 26254571 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
