Review
doi: 10.1038/nrm2395.
Transcriptional control of human p53-regulated genes
Affiliations
- PMID: 18431400
- DOI: 10.1038/nrm2395
Item in Clipboard
Review
Transcriptional control of human p53-regulated genes
Nat Rev Mol Cell Biol.
2008 May.
Abstract
The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
Similar articles
-
Comparative binding of p53 to its promoter and DNA recognition elements.J Mol Biol. 2005 May 6;348(3):589-96. doi: 10.1016/j.jmb.2005.03.014. J Mol Biol. 2005. PMID: 15826656
-
Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53.Mol Cancer Res. 2008 Nov;6(11):1732-41. doi: 10.1158/1541-7786.MCR-08-0208. Epub 2008 Oct 30. Mol Cancer Res. 2008. PMID: 18974396
-
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression.Oncogene. 2003 Jun 5;22(23):3645-54. doi: 10.1038/sj.onc.1206477. Oncogene. 2003. PMID: 12789273
-
Transcriptional regulation by p53: one protein, many possibilities.Cell Death Differ. 2006 Jun;13(6):951-61. doi: 10.1038/sj.cdd.4401916. Cell Death Differ. 2006. PMID: 16575405 Review.
-
Human tumor suppressor p53 and DNA viruses.Rev Med Virol. 2004 Sep-Oct;14(5):301-19. doi: 10.1002/rmv.431. Rev Med Virol. 2004. PMID: 15334538 Review.
Cited by
-
Mutant p53: one name, many proteins.Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112. Genes Dev. 2012. PMID: 22713868 Free PMC article. Review.
-
p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.Cell Syst. 2016 Apr 27;2(4):272-82. doi: 10.1016/j.cels.2016.03.006. Epub 2016 Apr 7. Cell Syst. 2016. PMID: 27135539 Free PMC article.
-
Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.Oncotarget. 2012 Feb;3(2):132-43. doi: 10.18632/oncotarget.447. Oncotarget. 2012. PMID: 22361592 Free PMC article.
-
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.Elife. 2015 Jun 1;4:e07270. doi: 10.7554/eLife.07270. Elife. 2015. PMID: 26030852 Free PMC article.
-
Alteration of DNA Damage Response Causes Cleft Palate.Front Physiol. 2021 Mar 29;12:649492. doi: 10.3389/fphys.2021.649492. eCollection 2021. Front Physiol. 2021. PMID: 33854442 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
