Corticotropin releasing hormone, receptor regulation and the stress response
- PMID: 18406298
- DOI: 10.1016/s1043-2760(98)00079-4
Corticotropin releasing hormone, receptor regulation and the stress response
Abstract
Corticotropin releasing hormone (CRH) coordinates behavioral, autonomic and hormonal responses to stress, including activation of the hypothalamic-pituitary-adrenal (HPA) axis with stimulation of adrenocorticotropin (ACTH) and glucocorticoids. Differential changes of expression of CRH and vasopressin(VP) in the parvicellular hypothalamic paraventricular nucleus (PVN), as well as regulation of CRH and VP receptors, are critical for the responsiveness of the HPA axis during stress. Pituitary CRH receptor (CRH-R)expression and content is controlled by the coordinated action of CRH, VP and glucocorticoids. Marked changes in hypothalamic and pituitary CRH-R expression support a key regulatory role for CRH in the HPA axis and the integrated stress response.
Similar articles
-
Regulation of pituitary ACTH secretion during chronic stress.Front Neuroendocrinol. 1994 Dec;15(4):321-50. doi: 10.1006/frne.1994.1013. Front Neuroendocrinol. 1994. PMID: 7895891 Review.
-
Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: implications for the pathophysiology of depression.Life Sci. 1998;62(22):1985-98. doi: 10.1016/s0024-3205(98)00027-7. Life Sci. 1998. PMID: 9627097 Review.
-
Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels.Endocrinology. 1995 Aug;136(8):3299-309. doi: 10.1210/endo.136.8.7628364. Endocrinology. 1995. PMID: 7628364
-
The stress system in the human brain in depression and neurodegeneration.Ageing Res Rev. 2005 May;4(2):141-94. doi: 10.1016/j.arr.2005.03.003. Ageing Res Rev. 2005. PMID: 15996533 Review.
-
Hypothalamo-pituitary-adrenal axis sensitization after chronic salt loading.Neuroendocrinology. 2001 Mar;73(3):185-93. doi: 10.1159/000054635. Neuroendocrinology. 2001. PMID: 11307037
Cited by
-
Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription.Endocrinology. 2010 Mar;151(3):1109-18. doi: 10.1210/en.2009-0963. Epub 2010 Jan 15. Endocrinology. 2010. PMID: 20080871 Free PMC article.
-
Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis.Front Mol Neurosci. 2018 Aug 30;11:305. doi: 10.3389/fnmol.2018.00305. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30214395 Free PMC article.
-
The molecular physiology of CRH neurons.Front Neuroendocrinol. 2012 Jan;33(1):67-84. doi: 10.1016/j.yfrne.2011.08.002. Epub 2011 Aug 18. Front Neuroendocrinol. 2012. PMID: 21871477 Free PMC article.
-
Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice.Curr Res Pharmacol Drug Discov. 2023 Jul 11;5:100161. doi: 10.1016/j.crphar.2023.100161. eCollection 2023. Curr Res Pharmacol Drug Discov. 2023. PMID: 37501771 Free PMC article.
-
Effects of simultaneous exposure to stress and nicotine on nicotine-induced locomotor activation in adolescent and adult rats.Braz J Med Biol Res. 2012 Jan;45(1):33-7. doi: 10.1590/s0100-879x2011007500153. Epub 2011 Nov 16. Braz J Med Biol Res. 2012. PMID: 22086465 Free PMC article.
LinkOut - more resources
Full Text Sources
Other Literature Sources
