Listeria comet tails: the actin-based motility machinery at work
- PMID: 18396046
- DOI: 10.1016/j.tcb.2008.03.001
Listeria comet tails: the actin-based motility machinery at work
Abstract
Listeria monocytogenes is a master of mimicry that uses the host cell actin system both to move within the cytoplasm of infected cells and for cell-to-cell spread. Recent studies of Listeria and similarly acting pathogens have generated leaps in our understanding of the actin-based force producing machinery. This machinery is essential for most motile properties of cells, not least for cell migration. In a minimal configuration, it consists of the Arp2/3-complex, Ena-VASP proteins, cofilin, capping protein and a nucleation-promoting factor. In this review, we discuss current models of pseudopodial protrusions and describe how the road to more complex models lies open and is already paved by recent studies using Listeria-based biomimetic motility assays.
Similar articles
-
Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.Nature. 1997 Jan 16;385(6613):265-9. doi: 10.1038/385265a0. Nature. 1997. PMID: 9000076
-
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.Nature. 1999 Oct 7;401(6753):613-6. doi: 10.1038/44183. Nature. 1999. PMID: 10524632
-
A role for cortactin in Listeria monocytogenes invasion of NIH 3T3 cells, but not in its intracellular motility.Cell Motil Cytoskeleton. 2006 Apr;63(4):231-43. doi: 10.1002/cm.20119. Cell Motil Cytoskeleton. 2006. PMID: 16489553
-
How do in vitro reconstituted actin-based motility assays provide insight into in vivo behavior?FEBS Lett. 2008 Jun 18;582(14):2086-92. doi: 10.1016/j.febslet.2008.02.065. Epub 2008 Mar 5. FEBS Lett. 2008. PMID: 18328266 Review.
-
How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force.Trends Microbiol. 1997 Jul;5(7):272-6. doi: 10.1016/S0966-842X(97)01048-2. Trends Microbiol. 1997. PMID: 9234509 Review.
Cited by
-
Mechanisms of spindle positioning.J Cell Biol. 2013 Jan 21;200(2):131-40. doi: 10.1083/jcb.201210007. J Cell Biol. 2013. PMID: 23337115 Free PMC article. Review.
-
Bacteria-Based Nanoprobes for Cancer Therapy.Int J Nanomedicine. 2024 Jan 23;19:759-785. doi: 10.2147/IJN.S438164. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38283198 Free PMC article. Review.
-
Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems.Trends Cell Biol. 2012 Dec;22(12):644-52. doi: 10.1016/j.tcb.2012.09.005. Epub 2012 Oct 8. Trends Cell Biol. 2012. PMID: 23059001 Free PMC article. Review.
-
Palmitate-mediated disruption of the endoplasmic reticulum decreases intracellular vesicle motility.Biophys J. 2023 Apr 4;122(7):1355-1363. doi: 10.1016/j.bpj.2023.03.001. Epub 2023 Mar 3. Biophys J. 2023. PMID: 36869590 Free PMC article.
-
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress.Vaccines (Basel). 2018 Jul 25;6(3):48. doi: 10.3390/vaccines6030048. Vaccines (Basel). 2018. PMID: 30044426 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
