doi: 10.1038/nm1747.
Epub 2008 Apr 6.
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Affiliations
- PMID: 18391962
- DOI: 10.1038/nm1747
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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Nat Med.
2008 May.
Abstract
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.
Comment in
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Assessing fetal nerve cell grafts in Parkinson's disease.Nat Med. 2008 May;14(5):483-5. doi: 10.1038/nm0508-483. Nat Med. 2008. PMID: 18463652 No abstract available.
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Pathology: The prion principle.Nature. 2016 Oct 27;538(7626):S13-S16. doi: 10.1038/538S13a. Nature. 2016. PMID: 27783578 No abstract available.
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