[Nucleotide excision repair in mammalia: mechanism of a primary damage recognition]
- PMID: 18389616
[Nucleotide excision repair in mammalia: mechanism of a primary damage recognition]
Abstract
Nucleotide excision repair is one of the most important pathways of DNA repair in eukaryotic cells. Defects of this system lead to serious diseases including certain kinds of cancer. Nucleotide excision repair is able to remove a wide range of the structurally diverse DNA damages such as UV induced pyrimidine dimers, bulky chemical adducts arising under the action of carcinogenic compounds or chemotherapeutical drugs on cellular DNA. A broad substrate specificity of this repair pathway is related to the main intriguing question that is the mechanism of damage recognition by the protein complex in the context of the large excess of undamaged DNA. This review is detailed on the key stage of nucleotide excision repair--the recognition of a lesion in DNA, which is still most debated. We have considered the main models of a primary damage recognition and preincision complex formation that have been suggested by the leading groups in this field. Data presented allow to suggest the model of sequential loading of the proteins of reparative complex on damage DNA as the most reasonable.
Similar articles
-
Nucleotide excision repair in higher eukaryotes: mechanism of primary damage recognition in global genome repair.Subcell Biochem. 2010;50:251-77. doi: 10.1007/978-90-481-3471-7_13. Subcell Biochem. 2010. PMID: 20012586 Review.
-
A molecular basis for damage recognition in eukaryotic nucleotide excision repair.Chembiochem. 2008 Jan 4;9(1):21-3. doi: 10.1002/cbic.200700619. Chembiochem. 2008. PMID: 18033706 No abstract available.
-
UV damage and repair mechanisms in mammalian cells.Bioessays. 1996 Mar;18(3):221-8. doi: 10.1002/bies.950180309. Bioessays. 1996. PMID: 8867736 Review.
-
Nucleotide excision repair: DNA damage recognition and preincision complex assembly.Biochemistry (Mosc). 2011 Jan;76(1):24-35. doi: 10.1134/s0006297911010056. Biochemistry (Mosc). 2011. PMID: 21568837 Review.
-
Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair.Chem Res Toxicol. 2010 Feb 15;23(2):432-42. doi: 10.1021/tx900444w. Chem Res Toxicol. 2010. PMID: 20092276
Cited by
-
Fluorescent probes for the analysis of DNA strand scission in base excision repair.Nucleic Acids Res. 2010 Apr;38(7):e101. doi: 10.1093/nar/gkq022. Epub 2010 Jan 27. Nucleic Acids Res. 2010. PMID: 20110254 Free PMC article.