Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin
- PMID: 18371508
- DOI: 10.1016/j.hrtlng.2007.10.002
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin
Abstract
Pulmonary manifestations of interferon (IFN) use are a rare but well known complication seen with both standard and pegylated interferon alpha-2b (pegIFNalpha-2b) forms of the agent. These are generally of modest intensity and reversible. We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure. Practicing gastroenterologists and intensivists alike need to be aware of the potential for serious pulmonary sequelae with the use of combination therapy for chronic hepatitis C viral (CHCV) infections.
Similar articles
-
Rhabdomyolysis associated with the co-administration of daptomycin and pegylated interferon α-2b and ribavirin in a patient with hepatitis C.J Antimicrob Chemother. 2012 Jan;67(1):249-50. doi: 10.1093/jac/dkr398. Epub 2011 Sep 29. J Antimicrob Chemother. 2012. PMID: 21965434 No abstract available.
-
Incidence of neutropenia and infections during combination treatment of chronic hepatitis C with pegylated interferon alfa-2a or alfa-2b plus ribavirin.Infection. 2008 Jun;36(3):250-5. doi: 10.1007/s15010-007-7132-6. Epub 2008 May 3. Infection. 2008. PMID: 18458815 Clinical Trial.
-
Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS.Chest. 2003 Jul;124(1):406-10. doi: 10.1378/chest.124.1.406. Chest. 2003. PMID: 12853555
-
Fatal cardiomyopathy associated with pegylated interferon/ribavirin in a patient with chronic hepatitis C.Eur J Gastroenterol Hepatol. 2006 Mar;18(3):287-9. doi: 10.1097/00042737-200603000-00010. Eur J Gastroenterol Hepatol. 2006. PMID: 16462543 Review.
-
[Interferon therapy for hepatitis B and C].Nihon Rinsho. 2007 Feb 28;65 Suppl 2 Pt. 1:559-63. Nihon Rinsho. 2007. PMID: 17455681 Review. Japanese. No abstract available.
Cited by
-
Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers.Pharmaceutics. 2014 Jun 20;6(2):333-53. doi: 10.3390/pharmaceutics6020333. Pharmaceutics. 2014. PMID: 24955820 Free PMC article.
-
Chest associated to motor physiotherapy improves cardiovascular variables in newborns with respiratory distress syndrome.Int Arch Med. 2011 Oct 26;4:37. doi: 10.1186/1755-7682-4-37. Int Arch Med. 2011. PMID: 22029840 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical