[Interactions and biological mechanisms of action of molecular signal peptides. I. Interleukin 1 (IL-1)]
- PMID: 1834620
[Interactions and biological mechanisms of action of molecular signal peptides. I. Interleukin 1 (IL-1)]
Abstract
Interleukin 1 (IL-1) has several fundamental immunoregulatory, haematological, metabolic and physiological effects. It coordinates the different cellular interactions in wound healing and inflammation, but most importantly it stimulates the activation and differentiation of pre-B-cells and T-cells, the attraction of neutrophils, the recruitment of bone marrow stem cells, the stimulation of the metabolism of arachnoid acid, the degradation of proteoglycans, an increase of body temperature and loss of appetite. An altered production of IL-1 or of IL-1 inhibitors may cause profound disturbances, as in AIDS, other viral and malignant diseases and in uncontrolled inflammatory processes. Since a variety of feedback mechanisms for the stimulation or inhibition of IL-1 production have been detected, a major research goal will be to analyse and correct as curly as possible any abnormalities of inflammation or wound healing. Completely new treatment methods might become available in the future through approaches interfering with the signal transduction or processing of IL-1, especially by IL-1 receptor antagonists (IL-1RA).
Similar articles
-
Biology of interleukin-1 (IL-1), with respect to otorhinolaryngology-head and neck surgery.Head Neck. 1994 Jan-Feb;16(1):88-94. doi: 10.1002/hed.2880160118. Head Neck. 1994. PMID: 8125795 Review.
-
Interleukin-1 and its receptor.Crit Rev Immunol. 1989;9(1):1-20. Crit Rev Immunol. 1989. PMID: 2523282 Review.
-
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist.Arthritis Rheum. 2005 Jul;52(7):2202-11. doi: 10.1002/art.21108. Arthritis Rheum. 2005. PMID: 15986350
-
IL-6 signal transduction and its physiological roles: the signal orchestration model.Rev Physiol Biochem Pharmacol. 2003;149:1-38. doi: 10.1007/s10254-003-0012-2. Epub 2003 Apr 5. Rev Physiol Biochem Pharmacol. 2003. PMID: 12687404 Review.
-
Aspects of cytokine induced modulation of immunity and inflammation with emphasis on interleukin 1.Arzneimittelforschung. 1988 Mar;38(3A):461-5. Arzneimittelforschung. 1988. PMID: 2969245