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Review
. 2008 Sep;87(8-9):507-15.
doi: 10.1016/j.ejcb.2008.01.011. Epub 2008 Mar 17.

Adhesions ring: a structural comparison between podosomes and the immune synapse

Sarah A Wernimont  1 , Christa L Cortesio, William T N Simonson, Anna Huttenlocher
Affiliations
Review

Adhesions ring: a structural comparison between podosomes and the immune synapse

Sarah A Wernimont et al. Eur J Cell Biol. 2008 Sep.

Abstract

Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

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Figures

Fig. 1
Fig. 1
Podosomes and the immune synapse share a common morphology. Schematic representation of the podosome and immune synapse shared ring-like structure. (A) Top view of podosomes and immune synapse. (B) Frontal view of podosome (adapted from (Linder and Aepfelbacher, 2003)) and immune synapse. For details, see text.
See this image and copyright information in PMC

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