Review
doi: 10.1016/j.cbpa.2008.01.019.
Epub 2008 Mar 7.
The Sirtuin family: therapeutic targets to treat diseases of aging
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- PMID: 18282481
- DOI: 10.1016/j.cbpa.2008.01.019
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Review
The Sirtuin family: therapeutic targets to treat diseases of aging
Curr Opin Chem Biol.
2008 Feb.
Abstract
Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven human Sirtuins (SIRT1-7) that display diversity in cellular localization and function. Growing evidence suggests that small-molecule activators of SIRT1 may counteract age-related afflictions such as type 2 diabetes. Alternatively, inhibitors of SIRT2 may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease. Recent discoveries of small-molecule and protein modulators of Sirtuin deacetylation activity have provided enormous insight into the biological and molecular functions of Sirtuins and have validated their potential as therapeutics.
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