H5N1 avian influenza re-emergence of Lake Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation
- PMID: 18272760
- PMCID: PMC2885753
- DOI: 10.1099/vir.0.83419-0
H5N1 avian influenza re-emergence of Lake Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation
Abstract
Highly pathogenic avian influenza H5N1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of Lake Qinghai, 2005. In May 2006, another outbreak struck Lake Qinghai and six novel strains were isolated. To elucidate these QH06 viruses, the six isolates were subjected to whole-genome sequencing. Phylogenetic analyses show that QH06 viruses are derived from the lineages of Lake Qinghai, 2005. Five of the six novel isolates are adjacent to the strain A/Cygnus olor/Croatia/1/05, and the last one is related to the strain A/duck/Novosibirsk/02/05, an isolate of the flyway. Antigenic analyses suggest that QH06 and QH05 viruses are similar to each other. These findings implicate that QH06 viruses of Lake Qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of Lake Qinghai.
Figures


Similar articles
-
Wild bird migration across the Qinghai-Tibetan plateau: a transmission route for highly pathogenic H5N1.PLoS One. 2011 Mar 9;6(3):e17622. doi: 10.1371/journal.pone.0017622. PLoS One. 2011. PMID: 21408010 Free PMC article.
-
Characterization of H5N1 influenza viruses isolated from migratory birds in Qinghai province of China in 2006.Avian Dis. 2007 Jun;51(2):568-72. doi: 10.1637/0005-2086(2007)51[568:COHIVI]2.0.CO;2. Avian Dis. 2007. PMID: 17626485
-
Highly Pathogenic Avian Influenza A Virus in Wild Migratory Birds, Qinghai Lake, China, 2022.Emerg Infect Dis. 2024 Oct;30(10):2135-2139. doi: 10.3201/eid3010.240460. Epub 2024 Aug 27. Emerg Infect Dis. 2024. PMID: 39190545 Free PMC article.
-
Clade 2.3.2.1 H5N1 avian influenza viruses circulate at the interface of migratory and domestic birds around Qinghai Lake in China.Vet Microbiol. 2019 Aug;235:234-242. doi: 10.1016/j.vetmic.2019.07.009. Epub 2019 Jul 11. Vet Microbiol. 2019. PMID: 31383307
-
Ecologic immunology of avian influenza (H5N1) in migratory birds.Emerg Infect Dis. 2007 Aug;13(8):1139-43. doi: 10.3201/eid1308.070319. Emerg Infect Dis. 2007. PMID: 17953082 Free PMC article. Review.
Cited by
-
A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India.Virol J. 2009 Feb 24;6:26. doi: 10.1186/1743-422X-6-26. Virol J. 2009. PMID: 19236725 Free PMC article.
-
Experimental infection of bar-headed geese (Anser indicus) and ruddy shelducks (Tadorna ferruginea) with a clade 2.3.2 H5N1 highly pathogenic avian influenza virus.Vet Pathol. 2013 Nov;50(6):961-70. doi: 10.1177/0300985813490758. Epub 2013 Jun 4. Vet Pathol. 2013. PMID: 23735616 Free PMC article.
-
Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.Sci Rep. 2015 Aug 11;5:12986. doi: 10.1038/srep12986. Sci Rep. 2015. PMID: 26259704 Free PMC article.
-
Prospective of Genomics in Revealing Transmission, Reassortment and Evolution of Wildlife-Borne Avian Influenza A (H5N1) Viruses.Curr Genomics. 2011 Nov;12(7):466-74. doi: 10.2174/138920211797904052. Curr Genomics. 2011. PMID: 22547954 Free PMC article.
-
Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from the H5N1 subtype of influenza A viruses.J Gen Virol. 2010 Apr;91(Pt 4):919-30. doi: 10.1099/vir.0.016766-0. Epub 2009 Dec 2. J Gen Virol. 2010. PMID: 19955560 Free PMC article.
References
-
- Chen, W., Calvo, P. A., Malide, D., Gibbs, J., Schubert, U., Bacik, I., Basta, S., O'Neill, R., Schickli, J. & other authors (2001). A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 7, 1306–1312. - PubMed
-
- Chen, H., Smith, G. J., Zhang, S. Y., Qin, K., Wang, J., Li, K. S., Webster, R. G., Peiris, J. S. & Guan, Y. (2005). Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436, 191–192. - PubMed
-
- Claas, E. C., Osterhaus, A. D., van Beek, R., De Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S., Shortridge, K. F. & Webster, R. G. (1998). Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351, 472–477. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical