doi: 10.1002/0471142727.mb0909s36.
Overview of the retrovirus transduction system
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- PMID: 18265289
- DOI: 10.1002/0471142727.mb0909s36
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Overview of the retrovirus transduction system
Curr Protoc Mol Biol.
2001 May.
Abstract
A retrovirus vector is an infectious virus used to introduce a nonviral gene into mitotic cells in vivo or in vitro. The efficient and precise integration machinery of naturally occurring retroviruses is utilized to produce either a single copy or a few copies of the viral genome stably integrated into a host chromosome. This unit presents an overview of the retrovirus life cycle and a description of vector designs and packaging cell lines.
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