HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
- PMID: 18264102
- DOI: 10.1038/ni1566
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
Abstract
Infection with human immunodeficiency virus 1 (HIV-1) results in the dissemination of virus to gut-associated lymphoid tissue. Subsequently, HIV-1 mediates massive depletion of gut CD4+ T cells, which contributes to HIV-1-induced immune dysfunction. The migration of lymphocytes to gut-associated lymphoid tissue is mediated by integrin alpha4beta7. We demonstrate here that the HIV-1 envelope protein gp120 bound to an activated form of alpha4beta7. This interaction was mediated by a tripeptide in the V2 loop of gp120, a peptide motif that mimics structures presented by the natural ligands of alpha4beta7. On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1.
Comment in
-
HIV's gut feeling.Nat Immunol. 2008 Mar;9(3):225-7. doi: 10.1038/ni0308-225. Nat Immunol. 2008. PMID: 18285769 No abstract available.
Similar articles
-
Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor.PLoS One. 2015 Dec 1;10(12):e0143895. doi: 10.1371/journal.pone.0143895. eCollection 2015. PLoS One. 2015. PMID: 26625359 Free PMC article. Clinical Trial.
-
Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.J Virol. 2017 Oct 13;91(21):e01005-17. doi: 10.1128/JVI.01005-17. Print 2017 Nov 1. J Virol. 2017. PMID: 28814519 Free PMC article.
-
Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains.J Virol. 2014 Sep;88(18):10767-77. doi: 10.1128/JVI.03296-13. Epub 2014 Jul 9. J Virol. 2014. PMID: 25008916 Free PMC article.
-
HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV.J Transl Med. 2011 Jan 27;9 Suppl 1(Suppl 1):S2. doi: 10.1186/1479-5876-9-S1-S2. J Transl Med. 2011. PMID: 21284901 Free PMC article. Review.
-
Integrin α4β7 in HIV-1 infection: A critical review.J Leukoc Biol. 2020 Aug;108(2):627-632. doi: 10.1002/JLB.4MR0120-208R. Epub 2020 Apr 9. J Leukoc Biol. 2020. PMID: 32272507 Review.
Cited by
-
Natural Immunity to HIV: a delicate balance between strength and control.Clin Dev Immunol. 2012;2012:875821. doi: 10.1155/2012/875821. Epub 2012 Dec 11. Clin Dev Immunol. 2012. PMID: 23304192 Free PMC article. Review.
-
The Mechanism of PEDV-Carrying CD3+ T Cells Migrate into the Intestinal Mucosa of Neonatal Piglets.Viruses. 2021 Mar 12;13(3):469. doi: 10.3390/v13030469. Viruses. 2021. PMID: 33809123 Free PMC article.
-
Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of α4β7 integrin.J Acquir Immune Defic Syndr. 2013 Nov 1;64(3):249-53. doi: 10.1097/QAI.0b013e3182a06ddd. J Acquir Immune Defic Syndr. 2013. PMID: 23797693 Free PMC article.
-
Impaired B cells survival upon production of inflammatory cytokines by HIV-1 exposed follicular dendritic cells.Retrovirology. 2016 Sep 5;13(1):61. doi: 10.1186/s12977-016-0295-4. Retrovirology. 2016. PMID: 27596745 Free PMC article.
-
LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20.Antimicrob Agents Chemother. 2009 Nov;53(11):4656-66. doi: 10.1128/AAC.00117-09. Epub 2009 Aug 31. Antimicrob Agents Chemother. 2009. PMID: 19721069 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
