Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy
- PMID: 1826023
- DOI: 10.1099/0022-1317-72-3-589
Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy
Abstract
Epidemiological investigation of a new incident of transmissible mink encephalopathy (TME) in Stetsonville, Wisconsin, U.S.A. in 1985 revealed that the mink rancher had never fed sheep products to his mink but did feed them large amounts of products from fallen or sick dairy cattle. To investigate the possibility that this occurrence of TME may have resulted from exposure to infected cattle, two Holstein bull calves were injected intracerebrally with mink brain from the Stetsonville ranch. Each bull developed a fatal spongiform encephalopathy 18 and 19 months after inoculation, respectively, and both bovine brains passaged back into mink were highly pathogenic by either intracerebral or oral inoculation. These results suggest the presence of a previously unrecognized scrapie-like infection in cattle in the United States.
Similar articles
-
Epidemiologic and experimental studies on transmissible mink encephalopathy.Dev Biol Stand. 1993;80:111-8. Dev Biol Stand. 1993. PMID: 8270100
-
Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters.J Gen Virol. 1992 Feb;73 ( Pt 2):329-34. doi: 10.1099/0022-1317-73-2-329. J Gen Virol. 1992. PMID: 1531675
-
Experimental infection of cattle with the agents of transmissible mink encephalopathy and scrapie.J Comp Pathol. 1995 Oct;113(3):241-51. doi: 10.1016/s0021-9975(05)80039-8. J Comp Pathol. 1995. PMID: 8592050
-
Transmissible mink encephalopathy.Rev Sci Tech. 1992 Jun;11(2):539-50. doi: 10.20506/rst.11.2.606. Rev Sci Tech. 1992. PMID: 1535524 Review.
-
Slow viral infections of animals: experimental models for human disease.Med Biol. 1981 Apr;59(2):77-84. Med Biol. 1981. PMID: 6273667 Review.
Cited by
-
Incongruity between Prion Conversion and Incubation Period following Coinfection.J Virol. 2016 May 27;90(12):5715-23. doi: 10.1128/JVI.00409-16. Print 2016 Jun 15. J Virol. 2016. PMID: 27053546 Free PMC article.
-
Afterthoughts about bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease.Emerg Infect Dis. 2001;7(3 Suppl):598-600. doi: 10.3201/eid0707.010744. Emerg Infect Dis. 2001. PMID: 11485682 Free PMC article. No abstract available.
-
Evaluation of the zoonotic potential of transmissible mink encephalopathy.Pathogens. 2013 Jul 30;2(3):520-32. doi: 10.3390/pathogens2030520. Pathogens. 2013. PMID: 25437205 Free PMC article.
-
Accelerated high fidelity prion amplification within and across prion species barriers.PLoS Pathog. 2008 Aug 29;4(8):e1000139. doi: 10.1371/journal.ppat.1000139. PLoS Pathog. 2008. PMID: 18769716 Free PMC article.
-
First report of a novel polymorphism and genetic characteristics of the leporine prion protein (PRNP) gene.Front Vet Sci. 2023 Sep 22;10:1229369. doi: 10.3389/fvets.2023.1229369. eCollection 2023. Front Vet Sci. 2023. PMID: 37808111 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
