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Review
. 2008 Mar;8(3):193-204.
doi: 10.1038/nrc2342.

DNA repair pathways as targets for cancer therapy

Thomas Helleday  1 , Eva Petermann, Cecilia Lundin, Ben Hodgson, Ricky A Sharma
Affiliations
Review

DNA repair pathways as targets for cancer therapy

Thomas Helleday et al. Nat Rev Cancer. 2008 Mar.

Abstract

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

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