Myocardial regeneration and stem cell repair
- PMID: 18243902
- DOI: 10.1016/j.cpcardiol.2007.11.002
Myocardial regeneration and stem cell repair
Abstract
Recent evidence would suggest that the heart is not a terminally differentiated organ and has the ability to regenerate itself under normal and pathophysiologic conditions. A major effort has been made to identify precursor cells that are capable of differentiating into cell lineages different from their organ of origin. Embryonic stem cells and bone marrow-derived cells (BMCs) have been studied and characterized, and BM precursor cells are currently being utilized as therapy in clinical trials of patients with heart failure of ischemic and nonischemic etiologies. Controversy remains, however, whether BMCs are the best cells to be used for replacement therapy. The existence of a cardiac stem cell (CSC) has also been described, which has the ability to generate new cardiac myocytes and blood vessels, raising the possibility of rebuilding a damaged heart with the organ's own precursor stem cell population. Animal studies have suggested such a possibility, and a clinical trial using CSCs is in progress. This monograph discusses our current understanding of myocardial regeneration and the roles that endogenous and exogenous stem cells may have in the future therapy of cardiovascular disease.
Similar articles
-
Cardiac stem cells and mechanisms of myocardial regeneration.Physiol Rev. 2005 Oct;85(4):1373-416. doi: 10.1152/physrev.00013.2005. Physiol Rev. 2005. PMID: 16183916 Review.
-
Endogenous cardiac stem cells.Prog Cardiovasc Dis. 2007 Jul-Aug;50(1):31-48. doi: 10.1016/j.pcad.2007.03.005. Prog Cardiovasc Dis. 2007. PMID: 17631436 Review.
-
Advances in cell-based therapy for structural heart disease.Prog Cardiovasc Dis. 2007 May-Jun;49(6):387-95. doi: 10.1016/j.pcad.2007.03.004. Prog Cardiovasc Dis. 2007. PMID: 17498519 Review.
-
Stem cell therapy for cardiac repair: benefits and barriers.Expert Rev Mol Med. 2009 Jul 8;11:e20. doi: 10.1017/S1462399409001124. Expert Rev Mol Med. 2009. PMID: 19586557 Review.
-
[New era of cardiac stem cell therapy in heart failure].Rinsho Byori. 2005 Jan;53(1):61-9. Rinsho Byori. 2005. PMID: 15724492 Review. Japanese.
Cited by
-
c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes.Clin Transl Sci. 2009 Feb;2(1):26-32. doi: 10.1111/j.1752-8062.2008.00089.x. Clin Transl Sci. 2009. PMID: 20443864 Free PMC article.
-
Adult Stem Cell Responses to Nanostimuli.J Funct Biomater. 2015 Jul 16;6(3):598-622. doi: 10.3390/jfb6030598. J Funct Biomater. 2015. PMID: 26193326 Free PMC article. Review.
-
Cell therapy with human MSCs isolated from the umbilical cord Wharton jelly associated to a PVA membrane in the treatment of chronic skin wounds.Int J Med Sci. 2014 Jul 11;11(10):979-87. doi: 10.7150/ijms.9139. eCollection 2014. Int J Med Sci. 2014. PMID: 25076843 Free PMC article.
-
The potential and challenges of using stem cells for cardiovascular repair and regeneration.Genes Dis. 2014 Sep 1;1(1):113-119. doi: 10.1016/j.gendis.2014.07.003. Genes Dis. 2014. PMID: 25642448 Free PMC article.
-
Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells.PLoS One. 2011;6(8):e24013. doi: 10.1371/journal.pone.0024013. Epub 2011 Aug 24. PLoS One. 2011. PMID: 21887363 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
