Review
doi: 10.1016/j.molcel.2007.12.010.
Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs
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- PMID: 18206964
- DOI: 10.1016/j.molcel.2007.12.010
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Review
Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs
Mol Cell.
.
Free article
Abstract
The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.
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